Multi-omics analysis indicates an association between TAPBP and prostate cancer.

Area of Science:

• Oncology
• Genetics
• Bioinformatics

Background:

• Prostate cancer is a prevalent malignancy in men globally, with surgery as the primary treatment.
• The underlying mechanisms of prostate cancer development and effective drug targets remain incompletely understood.

Purpose of the Study:

• To identify genes contributing to prostate cancer development.
• To discover potential therapeutic targets for prostate cancer treatment.

Main Methods:

• Integrated multidimensional and high-throughput data, including proteome-wide association studies (PWAS) and transcriptome-wide association studies (TWAS).
• Employed single-cell sequencing, functional enrichment, Mendelian randomization (MR), and Bayesian co-localization analyses.
• Screened for candidate genes associated with prostate cancer and clinical outcomes.

Main Results:

• Identified eight candidate genes with protein abundance associated with prostate cancer.
• Validated four of these genes at the transcriptome level.
• Through integrated analyses, pinpointed TAPBP as a single gene strongly associated with prostate cancer.

Conclusions:

• The study identified eight validated candidate genes, including MSMB, PLG, CHMP2B, ATF6B, EGF, TAPBP, GAS1, and MMP7.
• TAPBP emerged as a significant gene strongly linked to prostate cancer through advanced bioinformatic analyses.
• Findings provide potential targets for future prostate cancer research and therapeutic strategies.