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Multi-omics analysis indicates an association between TAPBP and prostate cancer

Xinlong Wang1,2, Aimin Jiang2, Chao Li1

  • 1Department of Urology, The Third Xiangya Hospital of Central South University, Changsha, China.

Plos One
|November 21, 2025
PubMed

Insights

Researchers identified genes linked to prostate cancer development and treatment. The study pinpointed TAPBP as a key gene strongly associated with prostate cancer, offering potential new therapeutic targets.

Area of Science:

  • Oncology
  • Genetics
  • Bioinformatics

Background:

  • Prostate cancer is a prevalent malignancy in men globally, with surgery as the primary treatment.
  • The underlying mechanisms of prostate cancer development and effective drug targets remain incompletely understood.

Purpose of the Study:

  • To identify genes contributing to prostate cancer development.
  • To discover potential therapeutic targets for prostate cancer treatment.

Main Methods:

  • Integrated multidimensional and high-throughput data, including proteome-wide association studies (PWAS) and transcriptome-wide association studies (TWAS).
  • Employed single-cell sequencing, functional enrichment, Mendelian randomization (MR), and Bayesian co-localization analyses.
  • Screened for candidate genes associated with prostate cancer and clinical outcomes.

Main Results:

  • Identified eight candidate genes with protein abundance associated with prostate cancer.
  • Validated four of these genes at the transcriptome level.
  • Through integrated analyses, pinpointed TAPBP as a single gene strongly associated with prostate cancer.

Conclusions:

  • The study identified eight validated candidate genes, including MSMB, PLG, CHMP2B, ATF6B, EGF, TAPBP, GAS1, and MMP7.
  • TAPBP emerged as a significant gene strongly linked to prostate cancer through advanced bioinformatic analyses.
  • Findings provide potential targets for future prostate cancer research and therapeutic strategies.

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