[Persistent myxoinflammatory fibroblastic sarcoma: an unusual case report and literature review]

myxoinflammatory fibroblastic sarcoma is a rare type of sarcoma characterized by the abnormal growth of mesenchymal tissue. It is known for its locally aggressive behavior, high recurrence rate, and potential for metastasis. Clinically, it typically presents as a superficial, painless subcutaneous mass, although it may sometimes cause pain and restricted movement. Histologically, comprises spindle cells with myxoid stroma and large atypical cells with marked nuclear pleomorphism, similar to Reed-Sternberg cells.

an 83-year-old woman presented with a lesion on the anterior region of her left leg. A comprehensive study protocol for a musculoskeletal tumor was initiated, followed by an incisional biopsy for histological and immunohistochemical analysis, which led to the diagnosis of myxoinflammatory fibroblastic sarcoma. The tumor was surgically resected, and the intraoperative and final report indicated negative surgical margins.

the patient experienced a favorable recovery and regained full mobility. Despite initial treatment and recovery, signs of local persistence were observed during follow-up four months later. The patient opted not to pursue the recommended treatment, choosing instead to continue monitoring the lesion.

this case underscores the importance of including myxoinflammatory fibroblastic sarcoma in the differential diagnosis of musculoskeletal lesions and highlights the need for multidisciplinary collaboration for accurate diagnosis and effective treatment.