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Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Predicting Differential Renal Function in Children With Vesicoureteral Reflux Using Ultrasound.

Oriol Martín-Solé1, Leopoldo Tapia Moral2, Sonia Pérez-Bertólez1

  • 1Pediatric Urology Unit, Pediatric Surgery Department, Hospital Sant Joan de Déu, Barcelona, Spain.

The Journal of Urology
|November 21, 2025
PubMed
Summary

Relative renal volume (RRV) measured by ultrasound accurately predicts differential renal function in children with vesicoureteral reflux (VUR). This noninvasive method may reduce the need for scintigraphy, lowering radiation exposure and costs.

Keywords:
kidney function testspediatricstechnetium Tc 99m dimercaptosuccinic acidultrasonographyvesicoureteral reflux

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Area of Science:

  • Pediatric Nephrology
  • Medical Imaging
  • Urology

Background:

  • Vesicoureteral reflux (VUR) is a common condition in children.
  • Assessing differential renal function is crucial for managing VUR.
  • Dimercaptosuccinic acid (DMSA) scintigraphy is the current standard but involves radiation exposure.

Purpose of the Study:

  • To evaluate if relative renal volume (RRV) by ultrasound can predict differential renal function in pediatric VUR patients.
  • To determine the accuracy of ultrasound-based RRV compared to DMSA scintigraphy.

Main Methods:

  • Retrospective review of 147 pediatric patients with unilateral primary VUR.
  • Collected data included renal volume by ultrasound (RRV) and differential renal function by DMSA scintigraphy.
  • Agreement between RRV and DMSA was analyzed using statistical methods.

Main Results:

  • A strong agreement was found between RRV and differential renal function (intraclass correlation coefficient 0.94).
  • RRV showed high sensitivity (89%) and specificity (89%) in predicting differential function below 40% using a 40% cutoff.
  • Ultrasound-based RRV is a reliable predictor of renal function.

Conclusions:

  • Relative renal volume (RRV) measured by ultrasound is an accurate, noninvasive predictor of differential renal function in children with unilateral VUR.
  • This ultrasound method may serve as an alternative to DMSA scintigraphy, reducing radiation exposure and healthcare costs.