Molecularly imprinted polymer-combined with metal organic frameworks (MIP/MOFs) for ratiometric fluorescence sensing...

Specific recognition is regarded as the most valuable feature of molecularly imprinted polymers (MIPs). Designing high-performance sensors with this property has emerged as a highly promising approach. In recent years, molecularly imprinted polymer/metal-organic framework (MIP/MOF) composites, a new class of porous materials, have been extensively explored for target-specific recognition. These materials offer several advantages, including high surface area, tunable structures, abundant active sites, and excellent recognition capabilities. They have been employed as ratiometric fluorescent sensors for the rapid and selective detection of various analytes in different samples with high sensitivity. This review presents the prevalent synthesis methods of MIP/MOFs and discusses the principles and classifications of MIP/MOF-based ratiometric fluorescent sensors. Their diverse applications across various fields, including the ratiometric sensing of drugs, antibiotics, biomolecules, contaminants, and more, are highlighted. Finally, the review outlines the prospects and future challenges of MIP/MOF development, providing valuable insights for the design of novel MIP/MOF materials.