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Updated: Jul 30, 2026

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
Published on: February 24, 2021
Spatial patterns of glioblastoma
1Department of Neurosurgery, Rogel Cancer Center, and Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Biointerfaces Institute and Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
Glioblastoma features extensive gene expression heterogeneity and high lethality, yet the mechanisms underlying this heterogeneity and its link to clinical outcomes remain elusive. In this issue of Cancer Cell, Migliozzi et al. spatially profile glioblastoma specimens to uncover cellular mechanisms that govern the extent of the heterogeneity in malignant cells.

