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Updated: Jun 18, 2026
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An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
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Immediate Postoperative cfDNA Elevation Predicts Pain After Robot-Assisted Radical Prostatectomy
Noritaka Ishii1, Tohru Yoneyama2, Satoko Minakawa3,4
1Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Summary
Immediate postoperative cell-free DNA (cfDNA) levels effectively predict pain severity after robot-assisted radical prostatectomy. This biomarker may enable personalized pain management strategies for patients undergoing surgery.
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Cell-free DNA (cfDNA) shows potential as a biomarker for surgical invasiveness.
- The predictive value of cfDNA for postoperative outcomes, particularly pain, requires further investigation.
Purpose of the Study:
- To evaluate if cfDNA levels measured immediately after robot-assisted radical prostatectomy (RARP) can predict postoperative pain and surgical stress.
- To compare cfDNA with conventional markers for pain prediction.
Main Methods:
- Retrospective analysis of 80 RARP patients.
- Measurement of cfDNA preoperatively and immediately postoperatively.
- Assessment of postoperative pain using the Numerical Rating Scale (NRS) and correlation with cfDNA levels and conventional stress markers.
Main Results:
- A higher cfDNA ratio was observed in patients with moderate-to-severe pain (NRS ≥ 4).
- Elevated cfDNA (≥ 2.00) was associated with increased odds of moderate-to-severe postoperative pain.
- Conventional markers like CRP and WBC count did not correlate with pain severity or cfDNA levels.
Conclusions:
- Immediate postoperative cfDNA is a sensitive biomarker for predicting pain severity after RARP.
- The cfDNA ratio may aid in developing personalized perioperative pain management.
- Prospective validation of these findings is recommended.
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