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Related Experiment Video

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Advanced Therapeutic Approach Based on LDHs-Mimetic Oxidoreductase.

Kai Song1, Yu Wei1, Peng Jia1

  • 1Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 21, 2025
PubMed
Summary

Layered double hydroxides (LDHs)-based nanozymes precisely remodel pathological microenvironments by modulating redox processes. This offers a promising therapeutic strategy for refractory diseases by reprogramming cellular redox homeostasis.

Keywords:
LDHs−based nanozymepathological microenvironmentredox process

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Redox dysregulation is a key driver in refractory diseases, impacting progression and prognosis.
  • Targeting redox processes in pathological microenvironments is a promising therapeutic strategy.
  • Layered double hydroxides (LDHs)-based nanozymes offer programmable multi-active sites for microenvironment remodeling.

Purpose of the Study:

  • To explore the redox modulating mechanisms of LDHs-based nanozymes in critical disease contexts.
  • To highlight the design of LDHs-based nanozymes for manipulating redox homeostasis.
  • To provide a forward-looking perspective on challenges and future directions.

Main Methods:

  • Systematic exploration of redox modulating mechanisms.
  • Emphasis on intrinsic enzyme-like activities and structure-activity relationships.
  • Review of recent advances in LDHs-based nanozyme design and application.

Main Results:

  • LDHs-based nanozymes enable precise pathological microenvironment remodeling.
  • These nanozymes can manipulate redox homeostasis for context-dependent therapeutic outcomes.
  • Demonstrated potential in conditions like tumors and tissue injury.

Conclusions:

  • LDHs-based nanozymes are effective tools for reprogramming pathological microenvironments.
  • They offer innovative therapeutic strategies by precisely modulating redox homeostasis.
  • Further research is needed to address current challenges and advance the field.