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  11. Gut Microbiota-driven Diseases And Intervention Strategies - Lessons From China

Gut microbiota-driven diseases and intervention strategies - lessons from China

Yingyu Zhou1,2,3, Ting Gong4, Chunzhi Yi4

  • 1School of Medicine and Health, Harbin Institute of Technology, Harbin, China. zhouyingyu13@hit.edu.cn.

NPJ Science of Food
|November 21, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Lifestyle changes in China impact the gut microbiome (GM), influencing non-communicable diseases (NCDs). This review explores Chinese lifestyle effects on GM and microbiome-targeted therapies for NCDs.

Area of Science:

  • Microbiome research
  • Public health
  • Nutritional science

Background:

  • Lifestyle factors significantly influence gut microbiome (GM) composition and function.
  • Urbanization in China has led to increased non-communicable diseases (NCDs) linked to dietary and activity pattern changes.
  • The gut microbiome plays a crucial role in the development of NCDs.

Purpose of the Study:

  • To review the impact of Chinese lifestyle factors on the gut microbiome.
  • To highlight mechanistic evidence of how gut commensals and metabolites affect NCD pathogenesis in China.
  • To explore traditional Chinese health practices as microbiome-targeted therapies for NCDs.

Main Methods:

  • Literature review of studies on lifestyle, gut microbiome, and NCDs in the Chinese population.

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  • Analysis of mechanistic evidence linking gut microbiota to disease development.
  • Identification and description of traditional Chinese health practices with microbiome-modulating potential.

    • Main Results:

    • Specific Chinese lifestyle patterns, such as unbalanced diets and sedentary behavior, induce gut dysbiosis.
    • Gut microbial metabolites can either prevent or promote the pathogenesis of common NCDs.
    • Traditional Chinese medicine, fermented foods, tea, and Tai Chi show potential as microbiome-targeted interventions.

    Conclusions:

    • Lifestyle-induced gut dysbiosis is a significant factor in prevalent NCDs in China.
    • Microbiome-targeted therapies derived from traditional Chinese practices offer novel treatment strategies.
    • Understanding these relationships can improve public health and disease management in China.