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Dietary acid load and mortality in the Japan Multi-Institutional Collaborative Cohort Study
Taichi Unohara1,2, Takeshi Watanabe3, Kokichi Arisawa1
1Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan.
Scientific Reports
|November 21, 2025
Summary
High dietary acid load, measured by net endogenous acid production (NEAP) score, is linked to increased mortality risk, particularly in Japanese men. This highlights the importance of diet in chronic disease prevention.
Area of Science:
- Nutrition Science
- Epidemiology
- Public Health
Background:
- Diet significantly influences the body's acid-base balance, potentially affecting chronic disease risk.
- Understanding the link between dietary acid load and mortality is crucial for public health strategies.
Purpose of the Study:
- To investigate the association between dietary acid load and all-cause and cause-specific mortality.
- To analyze these relationships in a large Japanese cohort.
Main Methods:
- A prospective cohort study involving 74,293 Japanese participants (aged 35-69).
- Dietary acid load estimated using the net endogenous acid production (NEAP) score.
- Cox proportional hazards regression analyses adjusted for confounders over an 11.6-year follow-up.
Main Results:
- Higher NEAP scores correlated with increased hazard ratios for all-cause mortality (HR 1.18).
- Increased risk observed for cause-specific deaths, including cerebrovascular disease.
- Associations were significant in males but not in females.
Conclusions:
- Dietary acid load may be a significant risk factor for all-cause and cause-specific mortality in Japanese men.
- Findings suggest potential sex-specific effects of dietary acid load on health outcomes.
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