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Updated: Jan 10, 2026
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
In vitro study on the bacteriostatic effect of Amoxicillin-loaded Nano-hydroxyapatite and its capability in occluding
Xinlei Xiong1,2, Aodi Li1,2, Zhenghao Zhang1,2
1Department of Oral Prosthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, 2 Jiangyang South Road, Luzhou, 646000, Sichuan, P.R. China.
Abstract:
This study explores the potential of Carboxymethy Cellulose/Amoxicillin/Nano-Hydroxyapatite suspensions (CMC/AMX/nHA) for the treatment of dentin hypersensitivity, particularly in the context of periodontitis treatment. The CMC/AMX/nHA suspension was compared with the commonly used clinical desensitizing agent Bifluorid12 and the broad-spectrum antibiotic Minocycline Hydrochloride. Microscopic observation and antimicrobial experiments were conducted to quantitatively and qualitatively assess the ability of CMC/AMX/nHA to seal dentinal tubules and its antimicrobial properties. Additionally, a resin bonding experiment was performed to evaluate the effect of CMC/AMX/nHA on dentin bonding. The research results indicate that CMC/AMX/nHA demonstrates good biocompatibility, with excellent drug delivery capabilities, bacterial growth inhibition, and no interference with subsequent repair treatments during desensitization therapy. These findings suggest that CMC/AMX/nHA has high translational potential and may be effectively applied in clinical oral medicine.
