Related Experiment Video

Updated: Jan 6, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
03:02

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

473

Efficacy of Bispectral Index-Guided Sevoflurane Administration in Pediatric Patients Undergoing General Anesthesia:

Kamil Derylo1, Nethra Sannasi1, Meisya Rosamystica2

  • 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

Paediatric Anaesthesia
|November 22, 2025
PubMed

Insights

Bispectral index (BIS) monitoring in pediatric patients undergoing sevoflurane anesthesia reduces anesthetic concentrations and speeds recovery. BIS guidance shortens extubation and post-anesthesia care unit discharge times.

Area of Science:

  • Anesthesiology
  • Pediatric Anesthesia
  • Clinical Monitoring

Background:

  • The bispectral index (BIS) is a tool for monitoring hypnosis depth.
  • Its role in guiding sevoflurane administration in pediatric patients requires further investigation.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy of BIS-guided sevoflurane administration in pediatric patients.

Main Methods:

  • A systematic review and meta-analysis of randomized controlled trials were conducted.
  • Searches included PubMed/MEDLINE, Embase, and Cochrane Register up to May 2025.
  • Analyses utilized RevMan 5.4.1., with heterogeneity assessed by the I² statistic.

Main Results:

  • Nine trials involving 730 pediatric patients were analyzed.
  • BIS-guided anesthesia significantly lowered end-tidal sevoflurane concentrations during maintenance and at surgery's end.
  • The BIS-guided group showed reduced time to airway removal and post-anesthesia care unit discharge.

Conclusions:

  • BIS-guided monitoring is effective in reducing sevoflurane dosage in pediatric anesthesia.
  • This approach accelerates airway extubation and post-anesthesia care unit discharge.
  • No significant difference in Pediatric Anesthesia Emergence Delirium was noted.
Abstract

Keywords:
Sevofluraneanesthesiabispectral indexelectroencephalographyinhalationintraoperative neuromonitoringpediatric

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