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Updated: Jan 10, 2026

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Published on: March 18, 2020
Different treatment modalities for advanced laryngeal cancer: improvement of oncological outcomes after tumor board
Mariana Gonçalves Rodrigues1, Daniel Marin Ramos1, Leandro Luongo de Matos1
1Head and Neck Surgery, Department of Surgery, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Introduction:
Laryngeal Squamous Cell Carcinoma (LSCC) has several treatment modalities available. Contrary to what has been observed in other cancers, the survival rates have worsened in recent years.
Methods:
Retrospective cohort study evaluating patients with T3 and T4a LSCC divided into two groups: those who were submitted to Total Laryngectomy (TL) or to Chemoradiation (CRT) or radiotherapy alone with curative intent between 2009 and 2019.
Results:
Three hundred and twenty patients were considered eligible to participate in the study, of which 166 (51.87%) submitted to TL and 154 (48.12%) to CRT. Overall survival in the surgical group was higher compared to the CRT group only between 2009 and 2013. In 2014, a multidisciplinary meeting was organized at the institution where the study took place, and both treatment modalities reached similar oncological outcomes.
Conclusion:
Multidisciplinary discussion among experienced professionals has a positive impact on oncological outcomes.
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