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Radiotherapy guidelines for gliomas: 2025 update
Delphine Antoni1, Emmanuel Mesny2, Osman El Kabbaj3
1Radiation Oncology Department, Institut de cancérologie Strasbourg Europe, Strasbourg, France.
Summary
This study updates French Society for Radiation Oncology guidelines for glioma radiotherapy. It emphasizes integrating molecular biomarkers and clinical factors for optimal treatment planning in brain tumor patients.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Medical Physics
Background:
- Gliomas are common malignant adult brain tumors.
- Radiotherapy for gliomas requires careful consideration of tumor characteristics and surrounding critical structures.
- Multimodal treatment including surgery, radiotherapy, and chemotherapy is standard for glioma management.
Purpose of the Study:
- To provide updated recommendations for radiotherapy in glioma patients.
- To outline indications and technical procedures for glioma radiotherapy.
- To integrate molecular biomarkers into treatment decision-making for brain tumors.
Main Methods:
- Review and update of existing guidelines by the French Society for Radiation Oncology.
- Inclusion of clinical factors (age, performance status) and tumor characteristics (histology, molecular biology, location).
- Consideration of radiotherapy techniques and dose prescription based on tumor radiosensitivity and proximity to organs at risk.
Main Results:
- Updated recommendations for radiotherapy indications in gliomas.
- Detailed technical procedures for performing radiotherapy on brain tumor patients.
- Emphasis on the essential role of molecular biomarkers in diagnostics and therapeutic decisions.
Conclusions:
- Molecular biomarkers are crucial for glioma diagnosis and treatment planning.
- Updated guidelines facilitate optimal radiotherapy strategies for brain tumor patients.
- Personalized radiotherapy approaches are essential for managing gliomas effectively.
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