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Updated: Jan 10, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Cytosolic DNA sensing pathway in senescence and aging: Underlying mechanisms and targeted interventions

Elaheh Alipour-Khezri1, Amin Moqadami1, Sepideh Zununi Vahed2

  • 1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 22, 2025
PubMed

Insights

Cellular senescence, a hallmark of aging, involves the cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) pathway. This pathway

Area of Science:

  • Molecular Biology
  • Immunology
  • Gerontology

Background:

  • Aging populations face increased healthcare demands due to age-related diseases.
  • Cellular senescence is a key aging characteristic, with the cGAS-STING pathway mediating inflammatory responses.
  • The cGAS-STING pathway detects cytosolic DNA, initiating inflammatory programs like the senescence-associated secretory phenotype (SASP).

Purpose of the Study:

  • To comprehensively review the molecular mechanisms of cGAS-STING in regulating cellular senescence and aging.
  • To elucidate the role of the cGAS-STING axis in age-related pathologies.
  • To discuss therapeutic interventions targeting the cGAS-STING pathway for age-related conditions.

Main Methods:

  • Literature review of studies on cGAS-STING pathway, cellular senescence, and aging.
  • Analysis of mechanistic insights into canonical and non-canonical cGAS-STING signaling in aging.
  • Synthesis of current research on therapeutic strategies targeting the cGAS-STING axis.

Main Results:

  • Age-dependent impairment of canonical cGAS-STING activation observed.
  • Emergence of non-canonical cGAS-STING signaling that sustains chronic inflammation and senescence.
  • The cGAS-STING pathway links DNA sensing to tissue degeneration in aging.

Conclusions:

  • The cGAS-STING pathway has a dual role in innate immunity and senescence-associated inflammation.
  • Dysregulation of cGAS-STING contributes to age-related diseases.
  • Targeting the cGAS-STING axis offers a promising therapeutic strategy to improve healthspan.
Keywords:
Age-related diseasesAntiagingCytoplasmic dsDNASenescent cellscGAS-STING

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