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Related Experiment Video

Updated: Jan 10, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
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Choroidal volume decrease associated with stromal regression in adult myopia: A high-resolution optical coherence

Na Su1, Xinpei Yuan1, Wenjie Yin1

  • 1Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.

Photodiagnosis and Photodynamic Therapy
|November 22, 2025
PubMed
Summary

Myopia progression is linked to decreased choroidal thickness and volume, mainly due to reduced stromal volume. This study used spectral-domain optical coherence tomography (SD-OCT) to analyze these changes in myopia patients.

Keywords:
Artificial intelligenceChoroid parametersHigh myopiaMyopiaOptical coherence tomography angiography

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Research

Background:

  • Myopia is a growing global health concern.
  • Understanding choroidal changes in myopia is crucial for disease management.

Purpose of the Study:

  • To investigate choroidal volume alterations in myopia of varying degrees using SD-OCT.
  • To correlate these changes with myopia severity and axial length.

Main Methods:

  • Spectral-domain optical coherence tomography (SD-OCT) was used to analyze 215 eyes from 118 myopia patients.
  • Patients were categorized into low, moderate, and high myopia groups.
  • Measurements included choroidal thickness (CT), choroidal volume (CV), vascular volume (VV), stromal volume (SV), choroidal vascular index (CVI), and choroidal capillary (CC) blood flow deficit (FD%).

Main Results:

  • Increased myopia severity correlated with decreased CT, CV, and SV, but increased CVI.
  • High myopia showed a higher foveal CC FD% compared to low and moderate myopia.
  • Mean CT and axial length were identified as independent protective and risk factors for high myopia, respectively.

Conclusions:

  • Myopia progression is associated with a reduction in choroidal thickness and volume.
  • Stromal volume reduction is the primary driver of these changes.
  • SD-OCT provides valuable insights into the structural adaptations of the choroid in myopia.