Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teeth01:15

Teeth

1.6K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.6K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.1K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.1K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

587
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
587

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of models of preclinical stage 2 bisphosphonate-related osteonecrosis of the jaw in non-rodent mammals using zoledronate: A systematic review.

Archives of oral biology·2026
Same author

Multicellular senescence programs in the aged heart.

Journal of molecular and cellular cardiology plus·2026
Same author

Three-dimensional analysis of maxillary asymmetry in patients with mandibular prognathism.

Maxillofacial plastic and reconstructive surgery·2026
Same author

Exercise-induced lactic acidemia associated with a SLC16A13 biallelic variant.

NPJ genomic medicine·2026
Same author

Targeting the CHD3 chromatin remodeler exploits a synthetic lethal vulnerability in dual SMARCA4/SMARCA2-deficient cancers via derepression of PARD3B.

NPJ precision oncology·2026
Same author

Natural senolytic activity of <i>Rhodiola rosea</i> extract alleviates age-associated phenotypes via paraptosis.

iScience·2026
Same journal

Zinc transporter ZIP13 in mesenchymal tissues: From intracellular metal distribution to systemic homeostasis.

Journal of oral biosciences·2026
Same journal

Relationship between ear canal deformation and mandibular condyle movement using an earplug-type sensor.

Journal of oral biosciences·2026
Same journal

Erratum to "Recent advances in the treatment of oral ulcerative mucositis from clinical and basic perspectives" [J Oral Biosci 66 (3) (September 2024) 504-510].

Journal of oral biosciences·2026
Same journal

Pathophysiology of orofacial neuropathic pain: A narrative review on the multi-level cascade of neuro-glial plasticity.

Journal of oral biosciences·2026
Same journal

Orthodontic force induces local bone resorption in mild-type hypophosphatasia mouse model.

Journal of oral biosciences·2026
Same journal

Corrigendum to "Histochemical analysis of osteoclast and osteoblast distributions on hydroxyapatite/collagen bone-like nanocomposite embedded in rat tibiae" [J Oral Biosci 67 (2025) 100612].

Journal of oral biosciences·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

9.3K

Senescence in palatal rugae development.

Finsa Tisna Sari1, Maiko Kawasaki1, Katsushige Kawasaki2

  • 1Division of Oral Anatomy, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Journal of Oral Biosciences
|November 22, 2025
PubMed
Summary
This summary is machine-generated.

Senescence-like cells are present during palatal rugae development, activated independently of p21. This cellular process, marked by senescence-associated β-galactosidase activity, was modulated by senolytic drugs.

Keywords:
MousePlacodeRugae developmentSenescencep21

More Related Videos

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

2.6K
Live Imaging of Mouse Secondary Palate Fusion
06:10

Live Imaging of Mouse Secondary Palate Fusion

Published on: July 27, 2017

8.0K

Related Experiment Videos

Last Updated: Jan 10, 2026

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

9.3K
Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

2.6K
Live Imaging of Mouse Secondary Palate Fusion
06:10

Live Imaging of Mouse Secondary Palate Fusion

Published on: July 27, 2017

8.0K

Area of Science:

  • Developmental Biology
  • Cellular Senescence

Background:

  • Periodic patterning is a conserved developmental mechanism across organs.
  • Palatal rugae in mammals serve as a model for studying periodic patterning.
  • Understanding the cellular basis of palatal rugae formation is crucial.

Purpose of the Study:

  • To investigate the role of cellular senescence in palatal rugae development.
  • To identify molecular mechanisms underlying senescence during this process.

Main Methods:

  • Analysis of senescence-associated β-galactosidase (SA-β-gal) activity in wild-type mouse embryos.
  • Examination of IL-6 and p21 expression during palatal rugae development.
  • Investigation of SA-β-gal activity in p21-deficient mice.
  • Assessment of senolytic drug efficacy on SA-β-gal activity.

Main Results:

  • SA-β-gal activity was detected in developing palatal rugae placodes (E12-14).
  • IL-6 and p21 expression correlated with SA-β-gal activity.
  • Senescence markers decreased by E16, coinciding with macrophage marker expression.
  • SA-β-gal activity persisted in p21-deficient mice and was reduced by senolytic drugs.

Conclusions:

  • Senescence-like cells are involved in palatal rugae development.
  • These cells are activated through a p21-independent pathway.
  • Senescence during palatal rugae development can be targeted by senolytic interventions.