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Related Concept Videos

Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

528
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
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Other Glycolytic Pathways01:24

Other Glycolytic Pathways

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The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
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Dextrin utilization in Streptococcus pyogenes pathogenesis and growth.

Yujiro Hirose1, Victor Nizet2, Shigetada Kawabata1

  • 1Department of Microbiology, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, 5650871, Japan.

Journal of Oral Biosciences
|November 22, 2025
PubMed
Summary
This summary is machine-generated.

Streptococcus pyogenes uses dextrin to boost growth and virulence. This carbohydrate metabolism reprogramming influences pathogenicity, highlighting its role in invasive diseases.

Keywords:
ArginineDextrinGrowthStreptococcus pyogenesVirulence

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Metabolic Engineering

Background:

  • Streptococcus pyogenes causes diverse infections, from mild to severe.
  • Nutrient availability significantly impacts S. pyogenes virulence.
  • Dextrin metabolism is linked to bacterial growth and pathogenicity.

Purpose of the Study:

  • To review how carbohydrate utilization influences S. pyogenes pathogenesis.
  • To understand the link between metabolic adaptation and virulence regulation.

Main Methods:

  • Literature review
  • Analysis of animal models
  • System-level analyses
  • Genome-scale metabolic modeling

Main Results:

  • The maltose/dextrin utilization operon enhances bacterial fitness and co-activates toxins.
  • Dextrin induces specific operons (nga-ifs-slo) and virulence regulatory systems (CovRS).
  • Dextrin promotes in vitro growth, potentially via increased arginine metabolism.

Conclusions:

  • Dextrin utilization is a key factor shaping S. pyogenes growth and virulence.
  • Dextrin acts as a regulatory cue, reprogramming bacterial virulence and metabolism.
  • Further research integrating metabolic modeling and experimental methods is needed to clarify its role in invasive diseases.