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Related Concept Videos

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Cyclodextrin-in-Liposome for therapy: Advances and challenges.

Petra Gerges1, Raya Gerges1, Paul Nguewa2

  • 1Faculty of Medicine, American University of Beirut, Lebanon.

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Summary
This summary is machine-generated.

Cyclodextrin-in-liposomes (CLs) enhance drug delivery by overcoming limitations of cyclodextrins and liposomes. These advanced carriers improve bioavailability and enable targeted delivery for various diseases.

Keywords:
CholesterolCyclodextrinCyclodextrin-in-liposomeDrug-in-cyclodextrin-in-liposomeLipid dropletsLiposome

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Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Cyclodextrins (CDs) are effective solubilizers but have poor oral bioavailability and rapid dissociation.
  • Liposomes can encapsulate hydrophobic drugs but face challenges with membrane stability and low loading rates.
  • Drug-in-cyclodextrin-in-liposomes (DCLs) were introduced to combine the benefits of CDs and liposomes.

Purpose of the Study:

  • To review the advantages of CD-in-liposomes (CLs) as drug delivery carriers.
  • To explore the potential of CLs and DCLs in transporting free CDs or CD/drug complexes.
  • To summarize literature on CL- and DCL-based formulations for disease treatment and their mechanisms.

Main Methods:

  • Literature review of scientific publications on CLs and DCLs.
  • Analysis of advancements in cyclodextrin and liposome technologies.
  • Examination of drug loading, stability, targeting, and in vivo distribution mechanisms.

Main Results:

  • CLs offer improved bioavailability and controlled release compared to standalone CDs.
  • Liposomes enable surface modification for targeted delivery, a challenge for CDs alone.
  • CLs and DCLs show promise in treating various diseases by enhancing drug efficacy and reducing side effects.

Conclusions:

  • CD-in-liposomes represent a significant advancement in drug delivery, overcoming limitations of individual components.
  • These nanocarriers offer versatile platforms for solubilizing hydrophobic drugs and enabling targeted delivery.
  • Further research into CL and DCL formulations holds great potential for novel therapeutic strategies.