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Updated: Jan 10, 2026

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Structure-activity relationships of sulfated polysaccharides in inflammatory bowel disease: Sources, mechanisms, and
Wendong Liu1, Mingyue Shen1, Jiahui Li1
1State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, China.
Abstract:
Inflammatory Bowel Disease (IBD), a chronic relapsing-remitting intestinal disorder, has emerged as a significant global health challenge with continuously rising incidence rates worldwide. Functionally active compounds and prebiotic supplements are increasingly recognized as effective strategies for improving gut health. Sulfated polysaccharides (SPs), derived from a wide range of sources, including animals, plants, microorganisms, and their metabolites, represent a class of beneficial functionally active compounds that have garnered substantial research attention for their potential therapeutic applications in IBD management. Nevertheless, the necessary analysis of the relationship between the structure of SPs and their anti-inflammatory bowel disease (anti-IBD) activity is currently lacking. This review comprehensively evaluates the evidence base regarding the sources of SPs, their anti-IBD activity (including in vitro and in vivo model systems), underlying mechanisms, and structure-activity relationships, highlighting the impact of the degree and the position of sulfate on IBD.
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