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Updated: Jan 10, 2026

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
Published on: September 19, 2025
Clinical technology advances driving in vivo CAR therapy
Yan-Ruide Li1, Yichen Zhu1, Lili Yang2
1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
In vivo chimeric antigen receptor (CAR) engineering has advanced into clinical trials with encouraging safety and efficacy. Technology breakthroughs, including targeted lipid nanoparticles, genetically modified lentiviruses, and optimized CAR constructs, have enabled precise, efficient, and safe gene delivery. This forum summarizes innovations accelerating the clinical translation of in vivo CAR engineering for immunotherapy.
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