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Related Concept Videos

Common Respiratory Disorders01:31

Common Respiratory Disorders

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Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
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Pneumonia I: Introduction01:30

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
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Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

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The pathophysiology of pneumonia involves the following steps:
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Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

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Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
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Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

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Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Clinical Characteristics And Epidemiological Analysis Of Respiratory Adenovirus Infection In Hospitalized Children.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Clinical Characteristics And Epidemiological Analysis Of Respiratory Adenovirus Infection In Hospitalized Children.

Related Experiment Video

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

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Clinical characteristics and epidemiological analysis of respiratory adenovirus infection in hospitalized children.

Jingjing Huang1, Qiongyu Wang1, Zhiqiang Zhuo2

  • 1Xiamen Children's Hospital/Children's Hospital of Fudan University at Xiamen/State-Level Regional Children's Medical Center, Huli District, NO. 92 Yibin Road, Huli District, Xiamen City, Fujian, 361006, China.

BMC Infectious Diseases
|November 22, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Human adenovirus (HAdV) is a common cause of pediatric respiratory infections, peaking in summer and winter. This study highlights a shift towards older children being more susceptible, while younger children face higher risks of co-infections.

Keywords:
AdenovirusInflammatory markersMixed infectionOlder children

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Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Epidemiology

Background:

  • Human adenovirus (HAdV) is a significant pathogen responsible for respiratory tract infections in children.
  • Understanding the epidemiology and clinical characteristics of HAdV is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical features and epidemiology of pediatric HAdV respiratory infections.
  • To provide data supporting the diagnosis, treatment, and control of HAdV in children.

Main Methods:

  • Retrospective analysis of 91 children diagnosed with HAdV infection at Xiamen Children's Hospital (June 2023 - May 2024).
  • Data included clinical characteristics, epidemiological factors, laboratory results, and co-infections.

Main Results:

Respiratory tract infection
  • HAdV accounted for 11.8% of respiratory infections, with peaks in February and August.
  • Older children (≥5 years) showed the highest detection rate (27.5%).
  • Acute upper respiratory tract infection was most common; adenovirus type 3 was identified. Younger children (<5 years) were more prone to co-infections.

Conclusions:

  • HAdV is a prevalent cause of pediatric respiratory infections across all ages.
  • A potential shift in susceptibility towards older children is observed.
  • Elevated inflammatory markers in some patients suggest an adenovirus-induced inflammatory response.