Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

3.1K

Tropomyosin 3 Gene Fusions in Cancers: From Mechanisms to Treatments-A Comprehensive Review

Anjie Chen1,2, Sixin Li1,2, Chen Guo1,2

  • 1Department of Urology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, China.

Cancer Medicine
|November 23, 2025
PubMed
Abstract

Insights

Tropomyosin 3 (TPM3) gene fusions drive cancer by activating tyrosine kinases. Targeted therapies show promise, but resistance and heterogeneity remain challenges in precision oncology.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Tropomyosin 3 (TPM3) is a key protein in muscle contraction.
  • TPM3 also plays a role in cancer development (oncogenesis).

Purpose of the Study:

  • Review the molecular mechanisms of TPM3 gene fusions.
  • Identify associated tumor types and clinical implications.

Main Methods:

  • Literature review of TPM3 gene fusions.
  • Analysis of oncogenic drivers and targeted therapies.

Main Results:

  • TPM3 fusions (e.g., TPM3-NTRK1, TPM3-ALK, TPM3-ROS1) act as oncogenic drivers.
  • These fusions lead to constitutive tyrosine kinase activation and tumorigenesis.
  • Tyrosine kinase inhibitors (TKIs) offer therapeutic relevance, but resistance and heterogeneity are challenges.

Conclusions:

  • TPM3 fusions are significant in various cancers.
  • Understanding these fusions aids diagnosis, prognosis, and targeted therapy.
  • Advances in precision oncology are fostered by insights into TPM3-related gene fusions.
Keywords:
gene fusiononcogenesistherapeutic targetingtropomyosin 3tumor progression

More Related Videos

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.1K
Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

9.9K

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.6K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K