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Intelligent Natural Hydrogels for Wound Therapy: Spatiotemporal Microenvironment Sensing, Synergistic Regulation, and
Han Wang1, Bingbing Pei2, Shuzhi Yao1
1Plastic and Reconstructive Surgery Center, The 964th Hospital, Changchun, Jilin, China.
Macromolecular Rapid Communications
|November 23, 2025
Summary
Natural hydrogels offer advanced wound healing by detecting and responding to wound signals. This review explores their design strategies and potential for personalized treatments in complex wound scenarios.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Wound healing is a global healthcare challenge.
- Traditional dressings lack responsiveness to wound microenvironments.
- Natural hydrogels show promise due to biocompatibility and modifiability.
Purpose of the Study:
- To systematically analyze natural hydrogels' microenvironmental response mechanisms in wound healing.
- To delineate synergistic design strategies for enhanced hydrogel function.
- To propose precise intervention pathways for complex wound types.
Main Methods:
- Review of natural hydrogel microenvironmental response mechanisms.
- Analysis of structural-functional-response synergistic design strategies.
- Integration of advanced validation techniques (organoids, 3D models, imaging, AI).
Main Results:
- Natural hydrogels can detect and regulate wound signals in situ.
- Synergistic design strategies include multi-modal networks, self-healing structures, and signal feedback.
- Tailored interventions are proposed for diabetic, infected, burn, and radiotherapy-induced wounds.
Conclusions:
- Natural hydrogels can evolve into diagnostic and therapeutic platforms.
- Advanced technologies enhance their validation and optimization.
- Challenges remain in achieving personalized and precise wound treatment.
