Related Experiment Video
Updated: Jan 10, 2026
10:05
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
Published on: March 20, 2017
12.6K
Bariatric Surgery Alters Oral Microbiome: Evidence From Obese Patients and a Mouse Model
Aaya Shahin1, Rachel Schyr2, Efrat Sharon3
1Department of Prosthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Israel.
International Dental Journal
|November 23, 2025
Summary
Bariatric surgery (BaS) worsens oral health and microbial balance in obese individuals, increasing risks for periodontal disease and cavities. This highlights the need for integrated dental and medical care post-surgery.
Area of Science:
- Oral microbiome research
- Bariatric surgery outcomes
- Periodontal disease and obesity
Background:
- Severe obesity is linked to gut and oral microbiome alterations.
- Oral dysbiosis increases the risk of periodontitis and dental caries.
- The impact of bariatric surgery (BaS) on oral health remains unclear.
Purpose of the Study:
- To investigate the effects of obesity and BaS on oral health and microbiota.
- To utilize both human cohorts and an experimental periodontitis (EP) obese mouse model.
Main Methods:
- Assessed oral health (gingivitis, caries, periodontitis) in pre-BaS, post-BaS, and control groups.
- Analyzed oral microbiome using 16S rRNA Next-Generation Sequencing (NGS).
- Investigated systemic parameters, bone volume, and oral/fecal microbiomes in obese mice with/without EP before and after BaS.
Main Results:
- Obese patients showed distinct oral microbial profiles compared to controls.
- Pre-BaS patients had higher oral microbial diversity and periodontitis-associated bacteria.
- Post-BaS patients exhibited increased caries- and halitosis-associated bacteria, mirroring mouse model findings.
Conclusions:
- BaS exacerbates obesity-related oral microbial dysbiosis, elevating risks for periodontal and dental diseases.
- Despite systemic health benefits, BaS may negatively impact oral health outcomes.
- Integrated medical-dental care and preventive strategies are crucial for patients undergoing BaS.
