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Related Experiment Video

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Emerin expression stratification across breast cancer subtypes.

Thaysa Ghiarone1, Emily Hansen2, James M Holaska2

  • 1Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ, 08103, USA.

Cancer Treatment and Research Communications
|November 23, 2025
PubMed
Summary

Reduced emerin protein expression in breast cancer correlates with aggressive tumor features. This nuclear envelope protein loss is linked to advanced stages, higher proliferation, and specific molecular subtypes, indicating its role in tumor progression.

Keywords:
Breast cancerEmerinMetastasisNucleoskeleton

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Nuclear dysmorphism is a key indicator of tumor aggressiveness.
  • Emerin, a nuclear envelope protein, maintains nuclear integrity and is linked to breast cancer aggressiveness.
  • Previous studies suggested an inverse correlation between emerin and breast cancer aggressiveness but lacked detailed analysis.

Purpose of the Study:

  • To investigate the correlation between emerin expression at the nuclear envelope and various breast cancer characteristics.
  • To assess emerin's relationship with tumor stage, grade, proliferation, and molecular phenotype in a large patient cohort.

Main Methods:

  • Quantitative analysis of emerin expression at the nuclear envelope.
  • Examination of 243 breast cancer patient samples with diverse tumor grades, stages, and molecular phenotypes.
  • Correlation analysis between emerin levels and clinical-pathological features, including Ki-67, HER2, ER, and PR status.

Main Results:

  • Significantly reduced emerin expression was observed in invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), and ductal carcinoma in situ (DCIS) compared to normal breast tissue.
  • Emerin loss correlated with advanced tumor stage, higher Ki-67 proliferation rates, elevated HER2, and decreased ER/PR expression.
  • Consistently reduced emerin expression was found in triple-negative breast cancer (TNBC) and other receptor-negative subtypes.

Conclusions:

  • Emerin expression is significantly reduced in various breast cancer subtypes, including invasive and in situ carcinomas.
  • Loss of emerin is associated with aggressive breast cancer phenotypes, including advanced stage, high proliferation, and specific receptor statuses.
  • Emerin deficiency may play a role in breast cancer dedifferentiation and progression, highlighting its potential as a biomarker.