Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

722
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
722
  1. Home
  3. Altered Neurobehavioral White Matter Integrity In Preterm Children: A Confounding-controlled Analysis Using The Adolescent Brain And Cognitive Development (abcd) Study.
  1. Home
  3. Altered Neurobehavioral White Matter Integrity In Preterm Children: A Confounding-controlled Analysis Using The Adolescent Brain And Cognitive Development (abcd) Study.

Related Experiment Video

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.7K

Altered neurobehavioral white matter integrity in preterm children: A confounding-controlled analysis using the

Hailong Li1, Yuwen Hung2, Junqi Wang3

  • 1Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Neurodevelopmental Disorders Prevention Center, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Neuroimage
|November 23, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Diffusion tensor imagingPreterm childrenWhite matter integrity

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.5K
Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice
06:34

Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

Published on: June 2, 2023

3.6K

Related Experiment Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.7K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.5K
Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice
06:34

Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

Published on: June 2, 2023

3.6K

Children born preterm show altered brain white matter integrity, impacting attention and processing speed. These findings highlight the need for early neuro-rehabilitation interventions to support healthy development.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatric Medicine

Background:

  • Premature birth is linked to atypical brain development and neurodevelopmental issues.
  • Limited understanding exists on outcomes unconfounded by medical complications.
  • This study investigates neural and behavioral outcomes in children born preterm without medical complications.

Purpose of the Study:

  • Identify unconfounded neurobehavioral biomarkers for childhood vulnerability after premature birth.
  • Examine neural and behavioral outcomes in non-medically complex preterm children.
  • Inform interventions to mitigate adverse outcomes in preterm populations.

Main Methods:

  • Utilized the Adolescent Brain and Cognitive Development (ABCD) Study dataset.
  • Employed a case-control design with rigorous confounding control.
  • Included 612 children (9-11 years): 306 preterm and 306 full-term, matched for key demographics.
  • Assessed neurocognitive outcomes and brain connectome integrity using diffusion tensor imaging (DTI).

    • Main Results:

    • Significant differences in microstructural and axonal integrity of frontal-limbic tracts between preterm and full-term children.
    • Altered structural connectivity in the anterior thalamic radiation was observed in preterm children.
    • A modified brain-behavioral regulatory relationship was found concerning attention and processing speed tasks.

    Conclusions:

    • Identified unconfounded neurobehavioral risk biomarkers associated with premature birth.
    • Preterm children exhibit reduced white matter integrity in the frontal-limbic connectome.
    • Diminished adaptability in attention and processing speed increases neurodevelopmental risk, necessitating targeted interventions.