Microscopic Spermatic Cord Denervation for Chronic Scrotal Content Pain Following Inguinal Hernia Repair: Outcomes

Makenna E Romanelli1, Bryan D Naelitz2, Raevti Bole2

  • 1Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Case Western Reserve University School of Medicine, Cleveland, OH.

Urology
|November 23, 2025
PubMed
Abstract

Insights

Microscopic spermatic cord denervation (mSCD) effectively treats chronic scrotal pain after inguinal hernia repair (IHR). Younger patients and those with levator tenderness may see less benefit from this procedure.

Area of Science:

  • Urology
  • General Surgery
  • Pain Management

Background:

  • Chronic scrotal content pain (CSCP) can significantly impact quality of life after inguinal hernia repair (IHR).
  • Microscopic spermatic cord denervation (mSCD) is a potential treatment option for refractory CSCP.
  • Identifying factors influencing treatment outcomes is crucial for patient selection and management.

Purpose of the Study:

  • To evaluate the effectiveness of mSCD in alleviating CSCP post-IHR.
  • To identify patient-specific or surgical factors associated with successful pain resolution following mSCD.

Main Methods:

  • Retrospective chart review of patients undergoing mSCD for CSCP after IHR.
  • Data collection included demographics, medical history, surgical details, and pain assessments.
  • Univariate regression analysis was used to determine predictors of pain resolution.

Main Results:

  • mSCD led to complete pain resolution in 43% and improvement in 87% of 47 cases.
  • Median follow-up was 7 weeks.
  • Younger patients (33 vs. 58 years) and those with levator tenderness/spasm (50% vs. 7%) were less likely to achieve pain improvement.

Conclusions:

  • mSCD offers significant palliation for CSCP following IHR in the majority of patients.
  • Younger age and a history of levator tenderness/spasm may predict poorer outcomes.
  • Referral to urology for consideration of mSCD is recommended for general surgeons managing these complex pain cases.