miRNAs in cardiovascular disease and an update on emerging trend in electrochemical biosensors for miRNA detection

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Cardiovascular Medicine

Background:

• Cardiovascular disease (CVD) is a major global health concern, necessitating early diagnosis for effective treatment and mortality reduction.
• Current diagnostic methods for CVD rely on traditional hospital equipment, involving lengthy procedures.
• There is a growing need for advanced, rapid, and accessible diagnostic tools for CVD screening.

Purpose of the Study:

• To review the development of electrochemical nanobiosensors for detecting blood-based RNA cardiac biomarkers.
• To evaluate the advantages and disadvantages of these advanced biosensing technologies for CVD diagnosis.
• To explore future research directions for RNA-based electrochemical nanobiosensors in cardiovascular disease management.

Main Methods:

• Focus on blood-based RNA cardiac biomarkers, a common clinical approach.
• Examination of electrochemical nanobiosensor platforms for RNA biomarker detection.
• Comprehensive review of existing literature on biosensing technologies for CVD.

Main Results:

• Nanotechnology and bioelectronics have enabled novel biosensor platforms for rapid, accurate, and continuous CVD marker monitoring.
• Electrochemical nanobiosensors show significant promise for the sensitive detection of RNA cardiac biomarkers.
• These biosensors offer a potential alternative to traditional, time-consuming diagnostic methods.

Conclusions:

• Electrochemical nanobiosensors represent a promising advancement for the early detection of cardiovascular disease.
• RNA biomarkers, when detected by nanobiosensors, can significantly improve diagnostic speed and accuracy.
• Further research into RNA-based electrochemical nanobiosensors is crucial for future CVD diagnostics and patient care.