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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

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Related Experiment Video

Updated: Jul 15, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Nanoparticles as Multifunctional Drug-Delivery Systems: A Comprehensive Review and Integration into Interventional

Kentaro Yamada1, Takeshi Suzuki1, Khashayar Farsad1

  • 1Dotter Department of Interventional Radiology, Oregon Health & Science University, Portland, Oregon.

Journal of Vascular and Interventional Radiology : JVIR
|November 23, 2025
PubMed
Summary

Nanoparticles offer advanced image-guided cancer therapy, improving drug delivery and overcoming limitations of traditional methods. This approach enables targeted treatment, real-time monitoring, and potential for novel therapies like gene editing.

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Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Oncology

Background:

  • Traditional intra-arterial cancer therapies face challenges like poor drug retention and tumor hypoxia, leading to resistance and metastasis.
  • Nanoparticles present a promising alternative for localized cancer treatment, offering enhanced drug delivery and overcoming intratumoral heterogeneity.

Purpose of the Study:

  • To review advancements in nanoparticle-based image-guided cancer therapy.
  • To discuss the potential of nanoparticles in overcoming limitations of conventional treatments and enabling theranostic applications.

Main Methods:

  • Review of current literature on nanoparticle applications in cancer therapy.
  • Discussion of nanoparticle design for targeted delivery, stimulus-responsive release, and theranostics.
  • Exploration of immunomodulatory nanoparticles and gene editing strategies.

Main Results:

  • Nanoparticles enable higher local drug concentrations and targeted delivery, potentially overcoming tumor resistance.
  • Theranostic nanoparticles integrate treatment with real-time monitoring via incorporated imaging agents.
  • Stimulus-responsive nanoparticles offer improved spatiotemporal drug release control.
  • Immunomodulatory nanoparticles show potential for enhancing immunotherapy and reshaping the tumor microenvironment.

Conclusions:

  • Nanoparticle-based strategies represent a significant advancement in image-guided localized cancer therapy.
  • Further research and clinical translation are needed to fully realize the potential of these advanced therapeutic platforms.
  • Synergistic approaches combining nanoparticle design with image-guided delivery hold promise for future cancer treatment innovations.