Next-Generation Approaches to Improve the Information Content of Interventional Radiology Biopsies

Area of Science:

• Interventional Radiology
• Analytical Technologies
• Oncology

Background:

• Image-guided core biopsies and fine needle aspirations (FNAs) are standard procedures in interventional radiology (IR).
• A significant limitation is the non-diagnostic rate, reaching up to 20% in some cases.
• Technical shortcomings contribute to these diagnostic failures.

Purpose of the Study:

• To highlight emerging multiplexed analytical technologies for tissue sampling.
• To demonstrate the potential of these technologies in enhancing information content and detection sensitivity from biopsies and FNAs.
• To discuss the future implications of these technologies in IR practices.

Main Methods:

• Review of emerging multiplexed analytical technologies relevant to tissue sampling.
• Discussion of applications in cellular heterogeneity and immune cell profiling.
• Exploration of potential impact on personalized medicine and therapeutic development.

Main Results:

• Multiplexed technologies offer enhanced information content from biopsies and FNAs.
• These technologies improve detection sensitivity, potentially reducing non-diagnostic rates.
• Applications include detailed cellular analysis and immune profiling.

Conclusions:

• Emerging multiplexed analytical technologies hold significant promise for improving tissue sampling in IR.
• These advancements can lead to better personalized clinical care and novel therapeutic strategies.
• The integration of these technologies is expected to be increasingly relevant in future IR practices.