Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Podospora bulbillosa keratitis: A case series with molecular confirmation from North-east India.

Indian journal of medical microbiology·2026
Same author

Reprogramming the lipid peroxidation product 4-ONE as a chemoselective cleavable crosslinker.

Nature communications·2026
Same author

Lysine methylation as a bidirectional switch.

Cell chemical biology·2026
Same author

Separating Signal from Noise: When Deep Learning Clarifies Physiology in MR Lymphangiography of Lower Extremity.

Radiology·2026
Same author

Clinical, gross, and microscopic findings in 7 owl monkeys (<i>Aotus spp</i>) with chronic biliary tree disease.

Veterinary pathology·2026
Same author

LATS1/2-CD38 Metabolic Rewiring Links Senescence to Intraplaque Thrombosis.

Circulation research·2026

Related Experiment Video

Updated: Jan 10, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.6K

Recent Developments and Future Directions in Image-Guided Chemistry.

Erik N K Cressman1, Monika Raj2, Erin H Seeley3

  • 1Department of Interventional Radiology, MD Anderson Cancer Center, Houston, Texas.

Journal of Vascular and Interventional Radiology : JVIR
|November 23, 2025
PubMed
Summary

Thermoembolization, a novel approach using in vivo chemistry, offers improved cancer treatment beyond traditional embolotherapy. This innovative method expands targeted therapies to include nondestructive protein modifications for enhanced outcomes.

More Related Videos

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
10:49

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Published on: September 20, 2016

13.2K
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

6.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.6K
Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
10:49

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Published on: September 20, 2016

13.2K
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

6.9K

Area of Science:

  • Interventional Radiology
  • Medical Chemistry
  • Oncology

Background:

  • Transcatheter embolotherapies have evolved significantly over 50 years, aided by advanced imaging like computed tomography (CT) and magnetic resonance (MR).
  • Despite technical advancements, a significant portion of tumors treated with embolotherapy still contain viable cancer cells upon microscopic examination.
  • Current limitations highlight the need for more effective therapeutic strategies in embolization treatments.

Purpose of the Study:

  • To introduce thermoembolization, a novel approach utilizing in vivo chemistry to enhance the efficacy of embolotherapy.
  • To explore the potential of basic chemical principles for developing more effective cancer treatments.
  • To present a new paradigm for targeted, image-guided in vivo chemistry, extending beyond destructive interventions to include nondestructive applications like protein modifications.

Main Methods:

  • Development of thermoembolization, a technique leveraging in vivo chemistry and chemical reactivity.
  • Investigation of unexpected chemical reactions for novel therapeutic applications.
  • Application of targeted, image-guided in vivo chemistry for both destructive and nondestructive interventions.

Main Results:

  • Thermoembolization demonstrates potential for more effective cancer treatments by addressing limitations of current embolotherapy.
  • The discovery of novel chemical reactions opens new avenues for therapeutic investigation.
  • A paradigm shift towards nondestructive interventions, such as protein modifications, is proposed.

Conclusions:

  • Thermoembolization represents a promising advancement in cancer therapy, integrating chemistry with interventional radiology.
  • The approach expands the scope of image-guided interventions to include precise molecular modifications.
  • This innovative strategy fosters interdisciplinary collaboration among interventional radiologists, chemists, and molecular biologists for future research and clinical applications.