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From Poser to Pro: Navigating the Subintimal Space and Managing Hematoma.
Jarrod D Frizzell1, Jesse A Kane2, Taishi Hirai3
1Complex Coronary Therapeutics, Heart and Vascular Institute, The Christ Hospital, Cincinnati, OH, USA.
Interventional Cardiology Clinics
|November 23, 2025
Summary
Mastering the subintimal space (SIS) is crucial for successful chronic total occlusions percutaneous coronary intervention (CTO PCI). Effective navigation and re-entry techniques improve outcomes in complex coronary interventions.
Area of Science:
- Cardiovascular Interventions
- Interventional Cardiology
Background:
- Chronic total occlusions (CTO) present significant challenges in percutaneous coronary intervention (PCI).
- The subintimal space (SIS) is a critical anatomical consideration during CTO PCI procedures.
Purpose of the Study:
- To highlight the importance of understanding and utilizing the subintimal space (SIS) for successful CTO PCI.
- To provide insights into techniques and tools for effective SIS navigation and management.
Main Methods:
- Discussion of relevant coronary pathology in CTO.
- Review of specialized equipment and wire technology for SIS navigation.
- Description of techniques for hematoma management and true lumen re-entry.
Main Results:
- Effective utilization of the SIS is essential for CTO PCI success.
- Specific tools and techniques enable operators to navigate the SIS proficiently.
- Improved management of hematomas and re-entry strategies enhance procedural outcomes.
Conclusions:
- Understanding and mastering the subintimal space is paramount for interventional cardiologists performing CTO PCI.
- The discussed techniques and technologies are vital for improving patient outcomes in complex coronary interventions.
- This knowledge empowers clinicians to enhance their skills and achieve better results in treating chronic total occlusions.

