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Metal-Organic Frameworks Against Tumor Metastasis: Therapeutic Targets, Strategies, and Challenges for Clinical
Jiahui Wang1, Xiuxiu Qiu2, Ruoyu Wang1
1Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abstract:
Tumor invasion and metastasis are the primary causes of cancer-related mortality and have a profound impact on patient prognosis. This review comprehensively examines the application of Metal-Organic Frameworks (MOFs) in anti-metastatic therapy and establishes a theoretical foundation for their clinical translation. A systematic literature analysis clarifies the structural and therapeutic profile of MOFs. These materials show significant promise for anti-metastatic therapy, leveraged by their high loading capacity, tunable responsiveness, and modifiable surface properties. This review discusses MOF-based multi-targeted strategies to combat metastasis, including tumor microenvironment modulation, targeting of key metastatic cells, and multimodal synergistic therapies. These approaches have demonstrated success in applications such as drug delivery, photodynamic therapy, and immune activation. The discussion further addresses critical challenges in biosafety and targeting efficiency for clinical translation, while recognizing how MOFs' structural versatility sustains their therapeutic development. This reviewaims to provide a theoretical foundation and practical framework for the innovative design and clinical translation of MOFs in anti-metastatic therapy.
Insights
Metal-Organic Frameworks (MOFs) show promise for anti-metastatic cancer therapy due to their unique properties. This review explores MOF applications, challenges, and their potential for clinical translation in combating cancer metastasis.
Area of Science:
- Materials Science
- Nanotechnology
- Oncology
Background:
- Tumor invasion and metastasis are leading causes of cancer mortality.
- Effective anti-metastatic therapies are crucial for improving patient prognosis.
- Metal-Organic Frameworks (MOFs) offer unique properties for therapeutic applications.
Purpose of the Study:
- To comprehensively review the application of MOFs in anti-metastatic therapy.
- To establish a theoretical foundation for the clinical translation of MOFs in cancer treatment.
- To explore MOF-based strategies for combating tumor metastasis.
Main Methods:
- Systematic literature analysis of MOF structures and therapeutic profiles.
- Examination of MOF-based multi-targeted strategies against metastasis.
- Review of MOF applications in drug delivery, photodynamic therapy, and immune activation.
Main Results:
- MOFs possess high loading capacity, tunable responsiveness, and modifiable surfaces beneficial for anti-metastatic therapy.
- MOF-based strategies effectively modulate the tumor microenvironment, target metastatic cells, and enable multimodal synergistic therapies.
- Successful applications include enhanced drug delivery, photodynamic therapy, and immune activation.
Conclusions:
- MOFs demonstrate significant potential for developing novel anti-metastatic therapies.
- Addressing challenges in biosafety and targeting efficiency is key for clinical translation.
- The structural versatility of MOFs supports their continued development in cancer therapy.
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