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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

2.1K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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The ABO Blood Group01:12

The ABO Blood Group

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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
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Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Related Experiment Video

Updated: Jan 10, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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Immobilized Enzymes for ABO-Independent Blood Cell Transfusions.

Christina Möller1, Fabian Pohlschröder2, Jan Wesche2

  • 1Department of Biotechnology and Enzyme Catalysis Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Straße 4, 17487, Greifswald, Germany.

Chembiochem : a European Journal of Chemical Biology
|November 24, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a method to create universal red cell concentrates (RCCs) and platelet concentrates (PCs) by enzymatically removing A and B antigens. This innovation addresses blood supply challenges and reduces transfusion incompatibility risks.

Keywords:
biocatalysisblood type antigensenzyme immobilizationglycoside hydrolasesuniversal blood

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Area of Science:

  • Biotechnology
  • Hematology
  • Enzymology

Background:

  • ABO compatibility is crucial for blood transfusions due to A and B antigens.
  • Declining donor numbers and rising demand strain the supply of red cell concentrates (RCCs) and platelet concentrates (PCs).

Purpose of the Study:

  • To develop a method for generating ABO-universal RCCs and PCs to overcome supply limitations.
  • To enzymatically remove A and B antigens from blood products while preserving their quality.

Main Methods:

  • Enzymatic removal of A antigen using enzymes from Flavonifractor plautii.
  • Enzymatic removal of B antigen using galactosidases from Pedobacter panaciterrae and Akkermansia muciniphila.
  • Immobilization of glycosidases on microparticles for easy removal via transfusion set filters.

Main Results:

  • B-positive red cells in RCCs reduced below 4% within 48 hours at 2-6°C.
  • Pooled PCs showed a 34% reduction in B-positive cells and a 4% residual A-positive platelet population after 4 hours at 20-24°C.
  • The method efficiently generates ABO-universal blood products, preserving quality and reducing incompatibility.

Conclusions:

  • Enzymatic antigen removal is a viable strategy for producing universal RCCs and PCs.
  • Immobilized enzymes offer a safe method for ABO antigen modification in blood products.
  • This approach enhances blood supply and transfusion safety.