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Updated: Jan 10, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Photoredox-Catalyzed Aminosulfonylation of gem-Difluoroalkenes via the Ritter Reaction
Raheel Ahmad1, Sakhawat Shah1, Liqiao Han1
1College of Chemistry, and Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, P. R. China.
Abstract:
A photocatalytic aminosulfonylation reaction of gem-difluoroalkenes, sulfonyl chlorides, and nitriles was successfully developed through a three-component Ritter-type reaction, with nitriles serving as both reactants and solvents. This efficient difunctionalization protocol is allowed for the synthesis of α,α-difluoromethyl-β-amidesulfonyl compounds in one step under mild conditions. The reaction exhibited broad functional group compatibility and particularly good reactivity with various nitriles. These products can be used as platform molecules for further modification. A possible mechanism was also proposed based on mechanistic experiments.
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