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Updated: Jan 10, 2026
11:17
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
14.3K
A real-world data-driven approach to optimizing enoxaparin dosing in burn patients
Babajide Shenkoya1, Venkata Yellepeddi2,3, Ann Marie B Prazak4
1Center for Translational Medicine, Department of Pharmacy Practice, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
British Journal of Clinical Pharmacology
|November 24, 2025
Summary
Optimizing enoxaparin dosing for burn patients using a population pharmacokinetic model significantly improves target anti-Xa levels compared to standard equation-based methods, especially for those with larger burn surface areas.
Area of Science:
- Pharmacokinetics and Pharmacodynamics
- Drug Dosing Optimization
- Burn Patient Management
Background:
- Enoxaparin dosing in burn patients is complex due to altered physiology.
- Current equation-based dosing often fails to achieve therapeutic targets.
Purpose of the Study:
- Develop a population pharmacokinetic (PK) model for enoxaparin in burn patients.
- Evaluate current equation-based (EQ) dosing effectiveness.
- Propose an optimized enoxaparin dosing regimen.
Main Methods:
- Analysis of real-world data from 408 burn patients.
- Development of a one-compartment PK model.
- Simulation of EQ dosing versus model-based dosing.
Main Results:
- Only 56% of patients achieved target anti-Xa levels with EQ dosing.
- Total burn surface area and body weight influenced enoxaparin PK.
- Model-informed dosing improved target attainment by over 70%.
Conclusions:
- A population PK model for enoxaparin in burn patients was successfully developed.
- Model-informed dosing enhances early prophylactic target attainment.
- This strategy optimizes enoxaparin use in high-risk burn patients.
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