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Updated: Jan 10, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
Psychological Impact of Biologic Therapy in CRSwNP: A Pilot Study
Alessandro Maselli Del Giudice1, Alessandra Sicolo2, Alessandro Mario Annarelli1
1Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Key Points:
Biologic therapies not only improve the inflammatory profile of chronic rhinosinusitis with nasal polyps (CRSwNP) but also appear to enhance patients' psychological well-being. Depression, anxiety, and stress levels significantly decrease after treatment with Dupilumab or Mepolizumab, suggesting a possible link between disease control and psychological improvement. This pilot study supports the integration of psychological assessment into the management of chronic airway diseases.
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