MODOMICS: a database of RNA modifications and related information. 2025 update and 20th anniversary
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Summary
This summary is machine-generated.The MODOMICS database, a key resource for RNA modifications, has been updated with expanded transcriptome-wide data and enhanced chemical structure analysis. This 20th-anniversary release strengthens its role in epitranscriptomics research.
Area Of Science
- Biochemistry
- Molecular Biology
- Bioinformatics
Background
- MODOMICS is a curated database for RNA modifications, integrating diverse data types.
- The field of epitranscriptomics is rapidly advancing, requiring updated resources.
Purpose Of The Study
- To present the 2025 update of the MODOMICS database, highlighting significant expansions and improvements.
- To enhance MODOMICS as a comprehensive resource for RNA modification research.
Main Methods
- Integration of transcriptome-wide data from Sci-ModoM for >48,000 transcripts.
- Systematic curation of modified residues and addition of quantum mechanical descriptors.
- All-versus-all chemical structure similarity analysis with an interactive graph.
- Updates to the protein section, including new enzymes and pathway annotations with an improved evidence framework.
Main Results
- MODOMICS now represents over 48,000 transcripts with high-confidence modification annotations.
- Enhanced computational descriptors and interactive exploration of chemical relationships among modifications.
- Updated protein information and improved evidence framework for modification pathways.
Conclusions
- The 2025 update significantly expands MODOMICS in scope and depth, reinforcing its status as a vital community resource.
- MODOMICS serves as a crucial reference and discovery platform for the evolving field of epitranscriptomics.
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