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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Related Experiment Video

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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CoRTE: a web-service for constructing temporal networks from genotype-tissue expression data.

Pietro Cinaglia1,2, Mario Cannataro2,3

  • 1Department of Health Sciences, Magna Graecia University, Catanzaro, 88100, Italy.

Bioinformatics Advances
|November 24, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces CoRTE, a web service for building temporal gene co-expression networks. CoRTE captures time-dependent gene interactions, crucial for understanding aging and diseases like Alzheimer's.

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Area of Science:

  • Network science
  • Systems biology
  • Bioinformatics

Background:

  • Understanding gene expression dynamics is key to biological mechanisms.
  • Static Gene Co-expression Networks (GCNs) fail to capture temporal changes.
  • There is a need for tools to analyze time-dependent gene interactions.

Purpose of the Study:

  • To design an open-source, user-friendly web service for constructing temporal networks from genotype-tissue expression data.
  • To overcome the limitations of static GCNs in reflecting biological changes over time.
  • To provide a tool for analyzing time-dependent gene interactions in biological processes.

Main Methods:

  • Developed COnstructing Real-world TEmporal networks (CoRTE), a web service.
  • CoRTE constructs temporal networks using statistical analysis of gene co-expressions across age ranges.
  • Applied CoRTE to analyze gene co-expression dynamics in brain tissues related to Alzheimer's Disease.

Main Results:

  • CoRTE successfully generated a temporal network from aging-related brain tissue data.
  • The generated network identified gene pairs with statistically significant co-expressions over time.
  • Results demonstrated CoRTE's ability to capture time-dependent gene interactions relevant to disease progression.

Conclusions:

  • CoRTE is an effective tool for constructing temporal gene co-expression networks.
  • The web service can reveal time-dependent gene interactions critical for aging and disease research.
  • CoRTE is suitable for exploring aging processes, disease development, and other time-dependent biological events.