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Updated: Jan 10, 2026

Isolation of Human Myoblasts, Assessment of Myogenic Differentiation, and Store-operated Calcium Entry Measurement
Published on: July 26, 2017
Molecular communication from bone to skeletal muscle: an overview
Guobin Li1,2, Mingyan Qi1, Yuzhen Wang1,2
1College of Life Sciences, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Bone and muscle communicate through novel "crosstalk," involving signaling molecules like osteokines and extracellular vesicles. This review highlights bone
Area of Science:
- Musculoskeletal biology
- Endocrinology
- Cell biology
Background:
- Traditionally, bone-muscle interaction was viewed as mechanical coupling.
- Emerging research reveals bone and muscle as endocrine organs communicating via signaling molecules.
- This communication is termed 'bone-muscle crosstalk'.
Purpose of the Study:
- To review current findings on bone-muscle crosstalk.
- To emphasize the roles of bone-derived osteokines and extracellular vesicles (EVs).
- To highlight connexin 43 (Cx43) channel functions in this crosstalk.
Main Methods:
- Literature review of recent studies on bone-muscle crosstalk.
- Focus on signaling molecules, EVs, and Cx43.
- Synthesis of current understanding and future directions.
Main Results:
- Bone influences muscle function through osteokines and EVs.
- Connexin 43 (Cx43) in osteoblasts/osteocytes mediates signaling molecule release via hemichannels and gap junctions.
- Bone-to-muscle signaling pathways are increasingly recognized.
Conclusions:
- Bone-muscle crosstalk is a critical pathway for musculoskeletal health.
- Osteokines, EVs, and Cx43-mediated signaling are key components.
- Understanding this crosstalk may reveal therapeutic targets for osteoporosis and sarcopenia.
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