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Histone H1 Promotes Silencing of Unintegrated HIV-1 DNA

Jiaqi Zhu, Gary Z Wang, Hugo D Pinto

    Biorxiv : the Preprint Server for Biology
    |November 24, 2025
    PubMed
    Summary

    Linker histone H1 knockdown reverses silencing of unintegrated human immunodeficiency virus type 1 (HIV-1) DNA, increasing viral expression. This effect is specific to HIV-1, not murine leukemia virus (MLV), revealing distinct H1 roles.

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