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Measurement of Fluid Pressure

Measurement of Fluid Pressure

Fluid pressure is commonly measured using devices called manometers, which rely on liquid columns to indicate pressure differences. The height of a liquid column in a manometer reflects the pressure exerted by the fluid, providing a simple yet effective means of measurement. Different types of manometers serve specific purposes based on their configurations and the type of fluids involved.
A basic form of manometer is the piezometer, a vertical tube open at the top and filled with the same...

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Related Experiment Video

Updated: Jan 10, 2026

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

Published on: April 25, 2013

Measuring Perfusion Pressure and Flow Resistance in a Microfluidic Device Using an External Optical System.

Matthew C Coughlin¹, Marie A Floryan², Giovanni S Offeddu²

¹Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115.

Biorxiv : the Preprint Server for Biology

|November 24, 2025

Summary

This summary is machine-generated.

Researchers developed a novel optical system to measure fluid forces in microphysiological systems (MPS). This tool quantifies flow and resistance in vascular structures, enhancing the physiological relevance of disease modeling.

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Last Updated: Jan 10, 2026

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Area of Science:

Biomedical Engineering
Physiological Modeling
Microfluidics

Background:

Microphysiological systems (MPS) are crucial for studying human disease pathology.
Incorporating organ-specific components increases MPS physiological relevance.
Accurate replication of physiological function requires appropriate physical forces, which are often unquantified in MPS.

Purpose of the Study:

To develop a simple, robust, and optically-based system for quantitative characterization of fluid flow in MPS.
To measure driving pressure and flow resistance within MPS vascular structures.
To ensure the system is suitable for long-term, sterile biological studies.

Main Methods:

An optically-based system was designed to interface with existing pumps.
The system quantitatively assessed fluid pressure and flow resistance.
Measurements were validated against hydrostatic methods and theoretical predictions for capillary flow.

Main Results:

The system demonstrated excellent agreement with established resistance measurement techniques.
It accurately quantified driving pressure and flow resistance in vascular structures within an MPS.
Measurements of vascular resistance in MPS were consistent with published data.

Conclusions:

The developed optical system provides a reliable method for quantifying physical forces in MPS.
This tool enhances the physiological relevance of MPS for disease modeling and drug development.
The non-invasive, sterile nature of the system is ideal for long-term biological applications.