Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.

Hossein Vahid Alizadeh¹, Andrea S Flores Pérez², Tomohiro Uno¹

¹Department of Orthopaedic Surgery, Stanford University, Stanford, USA.

Biorxiv : the Preprint Server for Biology

|November 24, 2025

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Recombinant OMV-Based Vaccine Elicits Potent Protective Immunity Against <i>Pseudomonas aeruginosa</i>.

Vaccines·2026

Same author

Long-term effects of a bony mucoperiosteal flap on bone preservation in bony impacted upper third molar surgery: a prospective exploratory study.

BMC oral health·2026

Same author

Enhanced pollutants removal and contributions analysis of near-natural floating bed coupling with microbial fuel cell.

Journal of environmental sciences (China)·2026

Same author

An Artificial Intelligence based model for predicting long-term all-cause mortality after acute Myocardial Infarction (the AIMI model).

European heart journal. Digital health·2026

Same author

Ginkgolide A enhances cardiomyocyte differentiation from pluripotent stem cells by targeting cytochrome c to attenuate intrinsic apoptosis.

The Journal of biological chemistry·2026

Same author

Age-related loss of Y chromosome is associated with mortality after ST-segment elevation myocardial infarction.

Communications medicine·2026

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

See all related articles

This summary is machine-generated.

This study introduces a 3D hybrid bioprinting platform for advanced tissue engineering. The novel approach creates robust, multifunctional constructs with enhanced mechanical strength for complex tissue applications.

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Conventional 3D bioprinting struggles to integrate soft and rigid materials for complex tissue constructs.
Existing methods limit the fabrication of multifunctional, mechanically robust engineered tissues.

Purpose of the Study:

To introduce a 3D hybrid bioprinting approach using the Hybprinter platform.
To demonstrate the fabrication of multi-material, multifunctional tissue constructs with enhanced properties.

Main Methods:

Utilized a novel Hybprinter platform integrating multiple 3D printing modules.
Employed a continuous bioprinting process with multiple soft and hard biomaterials.
Fabricated multi-hydrogel hybrid constructs with vascularization, mechanical robustness, and suturability.

Keywords:

biomaterials bioprinting multi-material biofabrication musculoskeletal therapeutics orthopedic grafts tissue engineering

More Related Videos

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

Related Experiment Videos

Last Updated: Jan 10, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

Main Results:

Achieved over a 1000-fold increase in mechanical strength compared to hydrogel-only constructs.
Demonstrated enhanced osteogenic and chondrogenic differentiation in cell-laden constructs.
Successfully integrated multi-material components, gradient properties, and bioactive agents.

Conclusions:

The 3D hybrid bioprinting approach offers robust biocompatibility and broad tissue engineering potential.
This versatile platform advances complex tissue engineering for patient-specific, organ-on-demand applications.
The technology enables the creation of mechanically strong, suturable, and multifunctional tissue constructs.