Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

8.7K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
8.7K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

6.8K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
6.8K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.2K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.2K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.4K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.4K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

988
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
988
Lobes of the Cerebrum01:22

Lobes of the Cerebrum

4.0K
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural synchrony between prefrontal and visual cortex supports visual working memory.

bioRxiv : the preprint server for biology·2026
Same author

Visual field map size constrains working memory precision.

bioRxiv : the preprint server for biology·2026
Same author

Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders.

Molecular psychiatry·2026
Same author

Illuminating posterior targets for TMS beyond the prefrontal cortex.

Nature. Mental health·2026
Same author

Dynamics of working memory drift and information flow across the cortical hierarchy.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Motion-corrected eye tracking improves gaze accuracy during visual fMRI experiments.

Nature communications·2025

Related Experiment Video

Updated: Jan 10, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.4K

Mnemonic maps of visual space in human prefrontal cortex.

Zhengang Lu, Logan T Dowdle, Kendrick N Kay

    Biorxiv : the Preprint Server for Biology
    |November 24, 2025
    PubMed
    Summary

    High-resolution brain imaging reveals that the superior precentral sulcus, not the midlateral prefrontal cortex (PFC), supports working memory. This finding impacts understanding of functional homologies and PFC working memory theories.

    More Related Videos

    Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
    08:45

    Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

    Published on: October 24, 2012

    15.1K
    Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
    06:17

    Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

    Published on: January 26, 2024

    2.6K

    Related Experiment Videos

    Last Updated: Jan 10, 2026

    Modeling the Functional Network for Spatial Navigation in the Human Brain
    05:55

    Modeling the Functional Network for Spatial Navigation in the Human Brain

    Published on: October 13, 2023

    1.4K
    Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
    08:45

    Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

    Published on: October 24, 2012

    15.1K
    Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
    06:17

    Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

    Published on: January 26, 2024

    2.6K

    Area of Science:

    • Neuroscience
    • Cognitive Neuroscience
    • Neuroimaging

    Background:

    • Neural theories of prefrontal cortex (PFC) function in working memory are largely based on macaque research.
    • Translating these findings to human PFC using neuroimaging has faced challenges, potentially due to insufficient resolution in prior studies.

    Purpose of the Study:

    • To investigate human PFC activity during working memory using high-resolution 7T fMRI.
    • To determine if finer neural resolution can resolve discrepancies between macaque models and human neuroimaging data for working memory.

    Main Methods:

    • Utilized 7T functional magnetic resonance imaging (fMRI) with 900-micron resolution to scan the human PFC.
    • Analyzed population activity in retinotopically organized regions during a working memory task.

    Main Results:

    • Population activity persisting during memory was found in the superior precentral sulcus, not the predicted midlateral PFC.
    • This activity encoded fine-grained information about memorized items and predicted behavioral errors.
    • A stable subspace with topological organization linked to visual space was identified.

    Conclusions:

    • High-resolution imaging reveals a distinct neural substrate for working memory in the human PFC (superior precentral sulcus).
    • Findings suggest potential functional homologies between human and macaque PFC in working memory mechanisms.
    • Revises theories on how the PFC supports working memory, emphasizing the role of specific subregions and neural resolution.