Related Experiment Video

Updated: Jul 14, 2026

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
12:01

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Published on: May 30, 2015

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Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

Elliot Keats Shwab1,2, Webb Pierson1,2, Daniel C Gingerich1,2

  • 1Division of Translational Brain Sciences, Department of Neurology, Duke University Medical Center, Durham, NC, 27710, USA.

Biorxiv : the Preprint Server for Biology
|November 24, 2025
PubMed
Summary

Researchers discovered a new alpha-synuclein (α-Syn) protein variant, α-Syn-115, in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). This variant, found in excitatory neurons, may drive disease progression by promoting protein aggregation.

Keywords:
Alpha-synucleinDementia with Lewy bodiesIsoformsLong-read sequencingParkinson’s diseaseProtein structureRNA splicingSingle-cell sequencingSynucleinopathiesTranscriptomics

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