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Related Experiment Video

Updated: Jan 10, 2026

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

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Published on: August 19, 2025

Disruption in Patterning in the Whisker-to-Barrel Cortex Pathway Alters Behavior.

Joanna M F Lutchman¹, Sarah A F Lutchman¹, Joshua C Brumberg^1,2

¹Department of Psychology, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.

Biorxiv : the Preprint Server for Biology

|November 24, 2025

Summary

This summary is machine-generated.

Mice whisker somatotopy disruption impacts behavior. Barrelless mice discriminated textures, while Prrxl1 knockout mice could not, with both showing anxiety.

Keywords:

Barrel Cortex Somatotopic Disruption Texture Discrimination Whisker-to-Barrel Pathway

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Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Published on: February 8, 2019

Area of Science:

Neuroscience
Sensory processing
Animal behavior

Background:

Mice utilize whiskers for sensory input, navigation, and environmental exploration.
The whisker-to-barrel pathway is crucial for processing tactile information.
Disruptions in this pathway can alter sensory perception and behavior.

Purpose of the Study:

To investigate the behavioral consequences of disrupted whisker somatotopy.
To compare the effects of absent barrel cortex patterning (Barrelless mice) versus disrupted lemniscal pathway patterning (Prrxl1 knockout mice).

Main Methods:

Utilized two mouse models: Barrelless (BRL) mice and Prrxl1 knockout (Prrxl1^-/-) mice.
Assessed whisker-dependent discriminatory behavior using a textured novel object recognition test.
Evaluated exploratory and locomotor behavior via an open field test.

Main Results:

Barrelless mice successfully discriminated textures, unlike Prrxl1^-/- mice.
Both BRL and Prrxl1^-/- mice exhibited increased anxiety compared to controls.
Exploratory and locomotor activity increased in BRL mice but decreased in Prrxl1^-/- mice.

Conclusions:

Whisker somatotopy disruption significantly affects sensory discrimination and exploratory behaviors.
The degree of pathway disruption correlates with specific behavioral phenotypes.
Somatosensory patterning is implicated in the regulation of anxiety and motor activity.