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Poisson's ratio is a material property that indicates their stress response. It explains the connection between the elongation or compression a material undergoes in the direction of an applied force and the contraction or expansion it experiences perpendicular to that force. When a slender bar is loaded axially, it stretches in the direction of the force and contracts laterally. Poisson's ratio is the negative ratio of this lateral contraction to the axial elongation. The negative sign ensures...

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Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

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Biased inter-columnar communication and short-term plasticity in mouse barrel cortex.

John M Judge, Meyer B Jackson

Biorxiv : the Preprint Server for Biology

|November 24, 2025

Summary

The barrel cortex (BC) uses direction-dependent circuits to process whisker information. This neural circuitry is tuned to whisking kinematics, enhancing temporal fidelity and filtering inputs based on phase and direction.

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Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Published on: August 19, 2025

Area of Science:

Neuroscience
Sensory processing
Computational neuroscience

Background:

The barrel cortex (BC) is crucial for processing whisker-mediated sensory information.
Whisker input has complex spatiotemporal structures influenced by whisking kinematics.
Understanding BC microcircuit communication is vital for deciphering sensory feature extraction.

Purpose of the Study:

Investigate communication within and between cortical barrels.
Elucidate how BC microcircuits extract spatiotemporal features from multi-whisker input.
Determine the role of synaptic transmission and inhibition in BC communication.

Main Methods:

Utilized a hybrid voltage sensor (hVOS) targeted to Scnn1a excitatory neurons in BC layer 4 (L4).
Imaged population responses to electrical stimulation in coronal and sagittal slices of mouse brain.
Employed AMPA receptor blockade to assess the role of excitatory transmission and inhibition.

Main Results:

Voltage imaging revealed an L4→L2/3→L4 relay crucial for inter-barrel communication.
AMPA receptor blockade confirmed reliance on excitatory transmission and uncovered feedforward inhibition.
Single-pulse responses showed direction-dependent latency and anisotropic short-term plasticity, particularly for protraction-related inputs.

Conclusions:

Identified direction-dependent synaptic circuitry shaping inter-barrel communication in the BC.
Short-term plasticity exhibits anisotropy aligned with whisker motion kinematics.
BC microcircuits are tuned to preserve temporal fidelity and selectively filter inputs based on whisking phase and direction.