Related Experiment Video
Updated: Jan 10, 2026
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Meta-analysis on clinical manifestation and laboratory parameters of COVID-19-associated multisystem inflammatory
Upendra Prasad1, Sunanda Jha1, Anand K Manjhi1
1Department of Pediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Insights
Multisystem inflammatory syndrome in children (MIS-C) linked to SARS-CoV-2 often presents with abdominal pain, shock, and rashes. Early diagnosis of MIS-C requires recognizing diverse clinical features and elevated inflammatory markers.
Area of Science:
- Pediatric Infectious Diseases
- Critical Care Medicine
- Rheumatology
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition associated with SARS-CoV-2 infection.
- Understanding the diverse clinical manifestations and laboratory findings of MIS-C is crucial for timely diagnosis and management.
Purpose of the Study:
- To systematically identify and summarize the clinical manifestations and laboratory parameters of COVID-19-associated MIS-C.
- To provide a comprehensive overview of the features of MIS-C to aid clinicians in diagnosis.
Main Methods:
- A systematic literature search was conducted using Google Scholar, PubMed, and Cochrane Library.
- Studies were selected based on keywords related to clinical characteristics and severity of MIS-C.
- Clinical characteristics and laboratory parameters from eligible studies were analyzed.
Main Results:
- A total of 44 studies involving 1840 patients with MIS-C were analyzed.
- Common symptoms included abdominal pain (74%), shock (72%), vomiting (69%), diarrhea (62%), and rashes (60%).
- Other significant findings were conjunctival infection (52%), myocarditis (49%), and Kawasaki disease-like presentations (44%).
Conclusions:
- COVID-19-associated MIS-C presents with multisystem involvement and elevated inflammatory markers.
- MIS-C can mimic Kawasaki disease, necessitating a high index of suspicion for diagnosis.
- Early identification of clinical features and lab parameters is essential for prompt treatment of MIS-C.
Objective:
We aimed to systematically identify clinical manifestations and lab parameters of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C).
Methods:
We searched from Google Scholar, PubMed, and Cochrane Library with the Medical Subject Heading (MeSH) key, which includes information about clinical characteristics and severity of patient's illness. We analyzed the clinical characteristics and lab parameters of MIS-C.
Results:
We identified a total of 44 eligible studies, including 1840 patients with COVID-19-associated MIS-C. Most common features were abdominal pain 74% (0.67,0.81), shock 72% (0.56,0.86), vomiting 69% (0.60,0.78), diarrhea 62% (0.53,0.72), rashes 60% (0.55,0.65), conjunctival infection 52% (0.44,0.60), others include myocarditis 49% (0.27,0.71), complete Kawasaki presentation 44% (0.23,0.66), respiratory distress 43% (0.16,0.73), oral mucosal changes 40% (0.31,0.49).
Conclusion:
The results of this review show that SARS-CoV-2-associated MIS-C can present with multisystem involvement and can show an increase in inflammatory markers. MIS-C can have presentationslike Kawasaki disease, which needs high index of suspicion to diagnose MIS-C. Clinical features and lab parameters help in early diagnosis and prompt treatment.
Related Concept Videos
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies