Applications of Robotic Exoskeletons as Motion-Assistive Systems in Cancer Rehabilitation

Robotic exoskeletons have emerged as promising motion-assistive technologies to meet the growing demand for structured, personalized cancer rehabilitation. This review critically examines their application in enhancing functional recovery, alleviating cancer-related fatigue, and improving quality of life among cancer patients and survivors. We first outline current evidence-based exercise strategies in cancer rehabilitation, followed by an analysis of how robotic exoskeletons complement and extend these approaches by restoring mobility, strengthening musculature, and supporting psychological well-being. Additionally, we assess how well they combine with multimodal interventions like nutritional, psychological, and digital therapeutics and their benefits. The convergence of artificial intelligence, wearable sensors, and telemedicine is also reshaping the landscape of remote, adaptive rehabilitation. Despite encouraging preliminary data, widespread clinical adoption remains limited due to challenges related to cost, exoskeleton system accessibility, safety, and long-term efficacy. We call for large-scale clinical trials, interdisciplinary collaboration, and policy reforms to promote equitable access to robotic-assisted rehabilitation. Collectively, this review offers a comprehensive perspective on the technical principles, therapeutic potential, and future directions of robotic exoskeletons as innovative tools in cancer recovery.