Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

185
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
185
Drug Product Stability01:16

Drug Product Stability

218
The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
218
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

289
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
289
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

204
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
204
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

168
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
168
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

176
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
176

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plough Fracture (Anterior Arch Fracture Type Traumatic Posterior Atlantoaxial Dislocation, TPAD-AOT Type III): A Retrospective Study of Nine Clinical Cases With Complete Imaging Data.

BioMed research international·2026
Same author

Traumatic posterior atlantoaxial dislocation based on imaging of the anterior arch-odontoid process-transverse ligament complex: a retrospective cohort study.

Journal of neurosurgery. Spine·2025
Same author

Validation of an Automated Method for the Isolation and Purification of Fat-Soluble Vitamins and Cholesterol for Chromatographic Analysis.

Journal of AOAC International·2025
Same author

Versatility of electrospun Janus wound dressings.

Nanomedicine (London, England)·2024
Same author

PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway.

International journal of biological sciences·2023

Related Experiment Video

Updated: Jan 10, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.5K

An Encapsulated Vitamin A Palmitate Powder With Improved Stability for Use in Food Fortification.

Samantha Brady1, Elsa Abou Jaoude2, Julie Wyns2

  • 1Particles for Humanity, PBC Cambridge Massachusetts USA.

Food Science & Nutrition
|November 24, 2025
PubMed
Summary

A new dry form of vitamin A palmitate (VAP), called PFH-VAP, shows significantly improved stability and recovery after cooking. This innovation offers a promising solution for large-scale food fortification to combat vitamin A deficiency (VAD).

Keywords:
cookingfood fortificationmethacrylatestabilityvitamin Avitamin A deficiency

More Related Videos

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.4K
Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination
06:02

Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

Published on: February 23, 2024

1.2K

Related Experiment Videos

Last Updated: Jan 10, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.5K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.4K
Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination
06:02

Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

Published on: February 23, 2024

1.2K

Area of Science:

  • Food Science
  • Nutritional Biochemistry
  • Public Health

Background:

  • Vitamin A deficiency (VAD) is a global health issue, particularly in developing nations.
  • Instability of vitamin A in fortified foods limits its effectiveness.
  • Existing vitamin A fortification methods face challenges with product degradation.

Purpose of the Study:

  • To develop a stable, dry form of vitamin A palmitate (VAP) for enhanced food fortification.
  • To create a powder with superior stability compared to commercially available vitamin A products.
  • To evaluate the efficacy of the new formulation in preventing VAD through fortified foods.

Main Methods:

  • Developed basic methacrylate copolymer (BMC)-encapsulated VAP (PFH-VAP) using spray-drying technology.
  • Assessed VAP content and recovery after cooking and accelerated stability testing.
  • Incorporated PFH-VAP and a commercial VAP into bouillon cubes for comparative stability analysis.

Main Results:

  • Laboratory-scale PFH-VAP showed over 90% VAP recovery post-cooking.
  • Pilot-scale PFH-VAP achieved 95% recovery post-cooking and 65% after accelerated stability testing.
  • PFH-VAP fortified bouillon retained 68-70% VAP after 12 months, significantly higher than the 15% from commercial VAP bouillon.

Conclusions:

  • PFH-VAP demonstrates a significant stability advantage over commercial VAP in a food matrix.
  • This stable VAP formulation has the potential to enhance the nutritional value of fortified foods.
  • PFH-VAP could be crucial in improving public health outcomes by preventing vitamin A deficiency.